In humans, mutations in CBP or EP300 are associated with Rubinstein-Taybi syndrome (RSTS) (http://omim.org/entry/180849, http://omim.org/entry/613684), an autosomal-dominant disorder characterized by mental and growth retardation and skeletal abnormalities [33], [34]. This evidence concerns the gene CREBBP and Rubinstein-Taybi syndrome.