Although Tmprss6 KO mice show a more severe iron deficiency anemia than control mice (Hb 97+/−1.5 vs 126+/−4.4 g/L [11]), liver iron content is comparable in the two groups (106.8+/−14.4 in Tmprss6 KO mice vs 101.8+/−11.6 μg iron/g liver in IDA animals) and does not significantly change after LPS treatment, as already reported for iron deficient animals [11]. Here, TMPRSS6 is linked to Iron deficiency anemia.