Interestingly, despite our findings that rectal tumors expressed moderate to high levels of FJX1 protein and that celecoxib treatment was associated with decreased expression of FJX1 mRNA in primary rectal cancer samples, we were unable to detect endogenous FJX1 protein expression in cultured colon cancer, human embryonic kidney or endothelial cells, and thus were unable to demonstrate a direct effect of celecoxib on FJX1 expression. The gene discussed is FJX1; the disease is rectal neoplasm.