The time- or dose-dependent inhibitions of pol ι were observed in HEK293, T24 and RT4 bladder cancer cells pre-treated for 2 hours with a JNK-specific inhibitor (SP600125) (Fig. 2D), even though the expression of pol ι in HEK293 cells appeared to increase at 48 hours. Here, MAPK8 is linked to urinary bladder carcinoma.