Also, sequencing data reveal that some of them are significantly mutated in cancers: Pi3k, Pten, and Akt in breast cancer [26], [27]; Ras and p53 in either breast and colorectal cancers [26], [28]; p53 and Nf1 in ovarian carcinoma [29]; p53 and Pten in small-cell lung cancer [30]; and Egfr, p53, Nf1, and Pi3k in human glioblastoma [31]. This evidence concerns the gene NF1 and colorectal cancer.