Of interest morphoproteomic analysis of insulin-like growth factor(IGF) pathway reveals constitutive activation of IGF-1receptor as evidenced by the expression of phosphorylated (p)-IGF-1R (Tyr1165/1166) on the plasmalemmal aspect and in cytoplasmic compartments of the tumor cells in DSCRT (Patient#1) (Figure 3). This evidence concerns the gene IGF1 and neoplasm.