In our longitudinal study, RA patients with persistently higher LDL cholesterol levels were in a persistently elevated inflammatory state, as determined by time-integrated ESR, time-integrated CRP, and DAS28, which is consistent with previous reports [12], [14]–[16], [20], [24]–[26], [38] that the inflammatory milieu adversely affects lipid profiles in RA. Here, CRP is linked to rheumatoid arthritis.