However, only less than half (17) of these enriched pathways have been reported in the arsenic CTD dataset (CTD_C009277_pathways) and 19 pathways were newly identified in the present study, including the top two most significantly altered pathways, Metabolic pathways, Proteosome (folding, sorting & degradation) and many others such as Protein processing in endoplasmic reticulum, PPAR signaling pathway, Pathways in cancer, MAPK signaling pathway, Hepatitis C, etc. (Table 2). The gene discussed is PPARA; the disease is hepatitis C virus infection.