KCNJ10 and EAST syndrome: Specifically, loss-of-function mutations in human Kir4.1 gene (KCNJ10) cause the EAST syndrome, including GTC seizures and ataxia (Bockenhauer et al., 2009; Scholl et al., 2009; Reichold et al., 2010; Sala-Rabanal et al., 2010; Tang et al., 2010).