KCNJ10 and status epilepticus: Elevation of Kir4.1 expression in the pilocarpine-induced TLE model was widely spread throughout brain regions examined and these changes were generally associated with an increase in the number of astrocytes, which was probably due to astrogliosis following status epilepticus-induced brain injury (Leite et al., 1990; Cavalheiro et al., 1991; Borges et al., 2003; Curia et al., 2008).