Compared to hyperlipidemic LDLR–/–ApoB100/100 controls, we found that IGF-II/LDLR–/–ApoB100/100 mice on a control or Western diet displayed altered retinal morphology and photoreceptor atrophy, suggesting the presence of retinal degeneration and a novel form of retinopathy. This evidence concerns the gene APOB and retinal degeneration.