APOB and hyperlipidemia: However, since no other changes in the sub-RPE space typical to hyperlipidemia were encountered and since IGF-II transgenic mice presented significantly more intraretinal changes than the LDLR–/–ApoB100/100 mice with similar plasma lipid levels, it is unlikely that hyperlipidemia would be the major underlying factor of the observed changes in the IGF-II/LDLR–/–ApoB100/100 mice.