We observed significant differences in the phenotype expression of glaucoma caused by the mutation p.Gln368Stop in MYOC. This mutation causes a premature terminal codon (PTC), and although located in the last exon of the MYOC gene, whether there is differential expression of the mutant allele in carriers, due for example to a nonsense-mediated messenger RNA decay (NMD) mechanism, remains to be determined. This evidence concerns the gene MYOC and glaucoma.