The two coding exons of CYP1B1 were analyzed with PCR and sequencing in 45 index patients with POAG, 25 index patients with PCG, 21 index patients with JOAG, four index patients with Axenfeld-Rieger syndrome (ARS), and seven index patients with other types of glaucoma (Table 2). The gene discussed is CYP1B1; the disease is Axenfeld-Rieger syndrome.