Furthermore, in family EMEEIG-12008 we found a patient with POAG (I:2) with a double mutation in CYP1B1, p.Ala179Argfsx16/p.Arg368His, while member II:2, who carries the compound heterozygous mutations p.Arg368His/p.Arg468-Ser476dup, remains asymptomatic. This evidence concerns the gene CYP1B1 and open-angle glaucoma.