Similarly, deletion of murine Stim1 severely impairs SOCE and the function of T cells (Oh-Hora et al, 2008), most evident in the inability of STIM1-deficient CD4+ T cells to mediate inflammation in animal models of autoimmune disease (Ma et al, 2010; McCarl et al, 2010; Schuhmann et al, 2010). The gene discussed is STIM1; the disease is autoimmune disease.