Impaired antitumour immunity and CTL function in Stim1fl/flStim2fl/flCd4Cre mice likely explain why human patients lacking SOCE due to mutations in the CRAC channel genes ORAI1 and STIM1 develop virus-associated malignancies such as EBV+ B cell lymphoma and HHV8+ Kaposi sarcoma (Byun et al, 2010; Fuchs et al, 2012). This evidence concerns the gene ORAI1 and B-cell non-Hodgkin lymphoma.