In several cases, chronic viral infections in ORAI1- and STIM1-deficient patients have caused Epstein–Barr virus (EBV)-positive B cell lymphoma and Human herpesvirus (HHV) 8-associated Kaposi sarcoma (Byun et al, 2010; Fuchs et al, 2012), suggesting that SOCE may be required for antitumour immunity by CD8+ T cells. This evidence concerns the gene ORAI1 and B-cell non-Hodgkin lymphoma.