WIF1 and cancer: Most of the published reports have indicated that WIF1 is a frequent target of epigenetic inactivation in cancers (Ding et al. 2009; Urakami et al. 2006; Mazieres et al. 2004; Ai et al. 2006; Clément et al. 2008; Chan et al. 2007; Taniguchi et al. 2005; Lin et al. 2007, 2008; Kim et al. 2007).