LMNA and Hutchinson-Gilford progeria syndrome: The LMNA gene (and protein complex) provided an example associated both with different phenotypes and a large variety of affected tissues (22), such as dilated cardiomyopathy (19,23), Charcot-Marie-Tooth disease (20), muscular dystrophy(21) or Hutchinson-Gilford progeria syndrome (24) (for details please refer to Supplementary Text S1).These LMNA-associated diseases have in common that they all show a high diversity of affected tissues (mainly heart, muscle and skin) and distinct phenotypes.