For ten investigated stromal cell lines/primary cells, the pharmacological effects on the constitutive release of 13 angioregulatory mediators were examined including CXCL8-12, Ang-1/2, VEGF, HGF, bFGF MMP-2, MMP-9 and MMP-10 (Table 5) and the results were compared with the effects on AML cells (see Table 4):. The gene discussed is ANGPT1; the disease is acute myeloid leukemia.