For reasons outlined above, we have endeavoured to prospectively investigate whether serum concentrations of selected risk markers of cardiovascular and neoplastic diseases, such as matrix metalloproteinases (MMP-2, MMP-9), their inhibitors (TIMP-1, TIMP-2), adiponectin and TSP-1 might change following radioiodine treatment of thy-rotoxicosis. Here, THBS1 is linked to neoplasm.