SNAP25 and multiple system atrophy: Moreover, given that SNAP-25 is reduced in the striatum of MSA brains [42], we speculate that a discontinuous pattern of αSyn pathologies usually found in MSA, i.e. glial cytoplasmic inclusions (GCIs) in the putaminal oligodendrocytes, and neuronal cytoplasmic inclusions (NCIs) and neuronal nuclear inclusions (NNIs) in the cortex [43,44], might be potentially linked through the presynaptic accumulation of αSyn in the corticostriatal neurons.