In addition, osteoclast- and tumour-induced acidosis in bone tissue may also contribute to the pathobiology of PCIBP by sensitizing subsets of sensory neurons that express the transient receptor potential vanilloid 1 (TRPV1) (Caterina et al. 2000) and/or the acid-sensing ion channel 3 (ASIC3) (Olson et al. 1998). Here, ASIC3 is linked to neoplasm.