CCDC86 and lymphoma: Importantly, CYCLON over-expression was specifically associated with poor survival of lymphoma patients treated with the current standard-of-care chemotherapy CHOP (Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulphate (Oncovin) and Prednisone) in combination with the monoclonal therapeutic antibody Rituximab (Nastoupil et al, 2012) but not in patients treated with chemotherapy alone.