INS and Insulin resistance: Indeed,p66Shc−/− mice are resistantto obesity induced by diet and leptin deficiency.74–75 Deletion ofp66Shc also seems to improve insulin sensitivity in obese diabetic mice on aSV/129 or mixed background, although this effect is controversial.76 As deletion of p66Shc prevents insulin‐resistance, delays aging,and protects from aging‐associated diseases, one wonders why p66Shc has been selected andwhat its physiological role is.