INS and Insulin resistance: Aging is also typically associated with impairedglucose tolerance, mainly because of a decline in insulin action.14–15 In contrast, high insulinsensitivity is linked to longevity, and parental longevity is inversely correlated with the risk ofdiabetes.16–17 A remarkable body of data in support of this mutual relationship is also availableand detailed in other reviews.18 From these works,it emerges that (1) insulin resistance can lead to ED, (2) ED can contribute to insulin resistance,and (3) both insulin resistance and ED accelerate aging.