Therefore, sirtuins exert an important role in mediating thelongevity of progenitor cells and, indirectly, may be a potentially useful tool for stimulatingendothelial repair, angiogenesis26 and protectionof the heart against ischemic insults.93 Metaboliccontrol can affect EPCs in both type 1 and type 2 diabetes.94–95 Again Balestrieri et al96 showed that the relationship between poor metaboliccontrol and EPC number is mediated by Sirt1; they showed that Sirt1 expression is reduced viaincreased platelet‐activating factor receptor activation. This evidence concerns the gene SIRT1 and type 2 diabetes mellitus.