Theseobservations emphasize possible relationships between telomeres, insulin resistance, and the p53tumor‐suppressor gene in the pathogenesis of cardiovascular disease; indeed, 1cross‐sectional study showed that higher circulating p53 levels are associated with anincrease in inflammatory markers, as well as increased carotid intima‐mediathickness.109 As p53 is inhibited by Sirt1 and itactivates p66Shc, studies are needed to demonstrate the concerted action of these elements onvascular homeostasis (Figure 2). The gene discussed is TP53; the disease is Insulin resistance.