Interestingly, hyperglycemia was shown to increase MiR‐217, promoting diabetescomplications.46 In addition, overexpression ofSirt appears to postpone the senescent phenotype of endothelial cells through Sirt‐inducedepigenetic modifications of protein or through mir‐34a.38 Collectively, these results are consistent with the concept that Sirt1 activityplays a major role in the prevention of CVD. Here, SIRT1 is linked to Hyperglycemia.