Given current efforts to develop LRRK2 kinase inhibitors [36], and the potential therapeutic use of these inhibitors in Parkinson's disease, it is clearly a priority to characterize the cellular impact of LRRK2 kinase inhibition, and a more detailed dissection of the mode of action of these inhibitors with regard to autophagy is an urgent need. The gene discussed is LRRK2; the disease is Parkinson disease.