To evaluate the effect of IgE on melanoma tumor growth, C57BL6/J (WT) mice were treated with a single i.v. administration of saline or monomeric IgE (750 ng/mouse) and twenty four hours later, mice were subcutaneously (s.c.)inoculated with B16 melanoma cells in one ear pinna and generated tumors were removed after four weeks. This evidence concerns the gene IGHE and melanoma.