However, our data showing a significant correlation between platelet count and Ang-1 levels only in patients with severe thrombocytopenia, but not in patients with higher and more variable platelet counts, suggest that severe hypoplastic thrombocytopenia could attenuate the influence of the pre-analytical variables that normally limit the determination of "true" Ang-1 levels. This evidence concerns the gene ANGPT1 and Thrombocytopenia.