It was interesting to note that the optimal cut-off of the Ang-2/Ang-1 ratio associated with septic shock in our population was very similar to the mean peak Ang-2/Ang-1 ratio observed in non-survivors in a study with non-neutropenic sepsis patients (5.0 vs 5.4, respectively) [11]. The gene discussed is ANGPT1; the disease is Sepsis.