The rapid adrenocorticotropic hormone (ACTH) stimulation test, in which a cortisol level less than 18 – 20 μg/dL at 60 minutes after ACTH challenge is regarded to be a poor response [9], revealed partial adrenal insufficiency in two cases with bilateral adrenal involvement without clinically apparent adrenal insufficiency. Here, POMC is linked to Adrenal insufficiency.