There are multiple triggering factors in chronic kidney disease (CKD) patients, but a significant proportion of episodes of hyperkalemia are attributed to the use of drugs taken to alleviate concomitant hypertension, especially angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) as they inhibit the renin-angiotensin system and cause a reduction in serum aldosterone [11]. This evidence concerns the gene REN and chronic kidney disease.