Il-1 blockade using selective IL-1β blockade (canakinumab) or IL-1 α and β blockade (anakinra, rilonacept) has proven efficacy in cryopyrin-associated periodic syndromes (CAPS) [1] and more recently in systemic-onset juvenile idiopathic arthritis (SJIA) [2-5]. The gene discussed is IL1B; the disease is cryopyrin-associated periodic syndrome.