These pathological features resemble the airways of FOXA2−/− mice [32], as well as the CF and COPD airways chronically infected by PA. Importantly, we have shown that PCN inhibits FOXA2 expression by activating the pro-GCHM signaling pathways Stat6 and EGFR [31,33]. The gene discussed is FOXA2; the disease is cystic fibrosis.