Regarding the association of Lp-PLA2 with cardiovascular disease, Hatoum et al. described that Lp-PLA2 activity was associated with incident coronary heart disease in patients with type 2 diabetes [29], but Nelson et al. reported that the Lp-PLA2 activity did not explain the excess of cardiovascular risk in diabetes [30]. The gene discussed is PLA2G7; the disease is cardiovascular disorder.