MUC5B and scleroderma: For instance, scleroderma affects mainly women, whereas IPF predominates in men; usual interstitial pneumonia is the pathological pattern of IPF, whereas non specific interstitial pneumonia is the main pattern in patients with scleroderma; the MUC5B promotor polymorphism is associated with IPF whereas it is not observed in patients with IPF [3]; IPF is rapidly progressive disorder as compared with the slowly moving scleroderma-associated lung fibrosis [2].