CD4 and systemic lupus erythematosus: In contrast to healthy children and T1DM patients, which presented with a similar CD4 + TCR Vβ repertoire pattern, 7 of the 9 SLE children tested displayed concurrently marked increased (mean value ± 3SD) and decreased usage (with even values of 0.0%) of several CD4 + Vβ subpopulations.