Amplification and point mutations of RelA were detected in human B-cell lymphomas such as Hodgkin lymphoma and to a lower extent also in T-cell lymphomas, reflecting the direct oncogenic potential of the NF-κB signaling pathway which was suggested since the initial discovery of the oncogenic RelA homologue v-Rel [88]. The gene discussed is RELA; the disease is B-cell non-Hodgkin lymphoma.