Another cancer that depends on NF-κB activity is melanoma, as it could be shown that HRas-mediated initiation of tumorigenesis requires IKK2-mediated NF-κB activation in a mouse model of melanoma [100] and even for lung cancer it could be demonstrated that IKK2 and NF-κB are crucial cofactors [101]. The gene discussed is NFKB1; the disease is lung cancer.