NLRP3 and colitis: In the present study, we showed that MitoQ suppresses ROS-promoted dissociation of TXNIP from TRX, inhibits the interaction between TXNIP and NLRP3 (Figure 4), and significantly decreases levels of IL-1 beta and IL-18 in the colons of mice with DSS-induced colitis (Figure 5A,B).