IgA nephropathies, defined as at least 1+ mesangial IgA deposits by immunofluorescence, are clinically divided in two groups:-primary IgAN, also called Berger’s disease which represent 90% of the cases, and-secondary IgAN observed in different clinical conditions: Henoch-Schönlein Purpura, HSP, alcoholic liver cirrhosis, some cases of Systemic Lupus Erythematosus, SLE, and few other rare conditions. Here, CD79A is linked to hereditary spastic paraplegia.