The conclusion is based on the following: (a) GL treatment caused a significant increase of cytoplasmic histone-associated DNA fragmentation in human breast cancer cells (Figure 2A), (b) an increase of caspase 3 activity was observed in GL-treated breast cancer cells (Figure 2B), and (c) the same GL treatment could not induce apoptosis in the normal human mammary epithelial cell HMEC (Figure 2D). This evidence concerns the gene CASP3 and breast cancer.