CASP3 and breast carcinoma: The conclusion is based on the following: (a) GL treatment caused a significant increase of cytoplasmic histone-associated DNA fragmentation in human breast cancer cells (Figure 2A), (b) an increase of caspase 3 activity was observed in GL-treated breast cancer cells (Figure 2B), and (c) the same GL treatment could not induce apoptosis in the normal human mammary epithelial cell HMEC (Figure 2D).