Univariable analysis of the data indicated that the factors significantly associated with persistent KpB as opposed to non-persistent KpB included higher Charlson’s comorbidity weighted index score, ICU admission, nosocomial infection, immunosuppressive therapy during the previous year, history of solid organ transplantation, invasive procedure during the previous 72 hours, fever and lack of CRP decrease on the second day after initial blood culture, ESBL-producing KpB, inappropriate empirical antibiotic use, and in-hospital mortality (Table 1). This evidence concerns the gene CRP and nosocomial infection.