Ethanol withdrawal produces anxiety-like behavior that is reversed by intracerebroventricular administration of CRF1/CRF2 peptidergic antagonists (121) and small-molecule CRF1 antagonists (122–, 124) and intracerebral administration of a peptidergic CRF1/CRF2 antagonist into the amygdala (125). This evidence concerns the gene CRHR1 and Anxiety.