Considering the efficacy of antidepressant drugs in the treatment of depression, we studied the effects of paroxetine (a selective 5-HT reuptake inhibitor) and imipramine (a 5-HT and NA reuptake inhibitor) in the tail suspension test (TST) and forced swimming test (FST) in Wfs1-deficient mice. The gene discussed is WFS1; the disease is major depressive disorder.