In the case of genetics, for example, many functional polymorphisms of the glucocorticoid receptor (GR), mineralocorticoid receptor (MR), corticotropin-releasing hormone (CRH), serotonin or other genes may modulate the link between prenatal anxiety and child outcomes, with one example with infant temperament so far reported (Pluess et al., 2011), although there are large-scale studies failing to replicate (Braithwaite et al., 2013), and so this question remains unresolved. The gene discussed is NR3C1; the disease is Anxiety.