IGF1 and sarcopenia: The progression of sarcopenia is affected by age-related systemic changes and by lifestyle habits.8 Age-related changes include reduction in anabolic hormones such as testosterone, estrogen, growth hormone, and insulin-like growth factor-1 (IGF-1), increased inflammatory activity, and oxidative stress which contribute to muscle catabolism.7 Lifestyle habits have a major impact on sarcopenia as well.