TARDBP and amyotrophic lateral sclerosis: TDP-43 is an aggregative-prone protein that when carrying specific mutations is linked to the development of amyotrophic lateral sclerosis (ALS).40 To test the possibility that IIS reduction alleviates the toxic effects of aggregative TDP-43 that carries disease-linked mutation, Zhang and colleagues created worms that express either wild-type fluorescently-tagged TDP-43 or the disease-linked, C terminal domain of the protein under the regulation of a pan-neuronal promoter.