RYR2 and catecholaminergic polymorphic ventricular tachycardia: In a recent study Jung et al. reported on the generation of iPSC from a 24-year-old CPVT1 woman carrying the novel RyR2 S406L mutation.39 The S406L mutation is located in the N-terminal domain of the RyR2 channel, which is one of the three hot spots for CPVT-associated RyR2 mutations.