When the cells were transplanted into mice, reduced growth, angiogenesis,and lymphangiogenesis were detected, and reduced expression of hypoxia-induciblefactor-1-α(HIF1-α), and vascular endothelia growth factor-A (VEGF-A),and VEGF-D were measured.54 Met-1breast cancer cells that over-express the viral oncogene PyVmT (polyoma virus middle Tantigen) show interaction of IGF-1R and IR with the PyVmT that increased with IGF-1 andinsulin presence. Here, INSR is linked to cancer.