Several in-depth studies found that T2D is associated with increased risk of developingcancer, regardless of obesity.11These studies distinguished the cancer sites related to T2D such as pancreaticcancer,16 extrahepatic biliarycancer,17 breast cancer,especially estrogen receptor-positive breast cancers;18,19 but it seems to have no effect on the incidence of premenopausal breastcancer.19 No link was foundbetween T2D and lung cancer.8,20. Here, ESR1 is linked to breast carcinoma.