The igf2 gene is maternally imprinted in mouse and human.Igf2 gene imprinting is involved in Beckwith–Wiedemannsyndrome and Wilms’ tumor.56 Transgenic over-expression of IGF-2 in lung epithelium induces lung tumorsthrough IGF-1R signaling pathways.57 In a mouse model of colon cancer, IGF-2 increased tumor development on thebackground of adenomatous polyposis coli (APC) gene mutation.58 in addition, IGF-2 can bind to the insulinreceptor (IR-A) and activate mitogenic effects. Here, IGF2 is linked to Nephroblastoma.