IGF1 and malignant colon neoplasm: Addition of IGF-1 to colon cancer celllines caused re-localization of integrins which resulted in increased cellmigration.42 Another cellmotility feature, the lamellipodia, was found to be induced by IGF-1 in melanoma andneuroblastoma cancer cell lines.43 In order to understand the role of the IGF-1R in tumorigenesis, animalstudies have investigated modulation of the IGF-1R.