HPSE and plasma cell myeloma: For example, enhanced expression of either HSulf-1 or HSulf-2 attenuated myeloma tumor growth.94 An even more dramatic inhibition of tumor growth was noted following administration of bacterial heparinase III (heparitinase) to SCID mice inoculated with myeloma cells isolated from the bone-marrow of myeloma patients.58 Unlike the bacterial enzyme, heparanase cleaves HS more selectively and generates fragments that are 4–7 kDa in size, yielding strictly distinct outcomes in the context of tumor progression.