It also stimulates endothelial mitogenesis, primarily through release of HS-bound growth factors (i.e. fibroblast growth factor (FGF), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF)) residing in the ECM.16,17 Tumor cells appear to use the same molecular machinery during metastasis and neoangiogenesis (Figure 1). This evidence concerns the gene HGF and neoplasm.