Heparin is a potent inhibitor of heparanase, but its use at high doses is impossible due to the potential for anticoagulant activity.83 Interestingly, low-molecular-weight heparin (LMWH), being more bioavailable and less anticoagulant than heparin, appears to prolong survival of patients with cancer. The gene discussed is HPSE; the disease is cancer.