To delineate the mechanism(s) of N-AChE-S-induced apoptosis we hence searched for protein partners in vitro and found that GSK3, the Aurora and cyclin-G-dependent kinases (GAK), membrane integrin receptors and the death receptor FAS all interact with N-AChE-S.18 Therefore, N-AChE-S seems to be a key factor in apoptosis, especially in the AD-related context of calcium dys-homeostasis and tau hyperphosphorylation. This evidence concerns the gene ACHE and Alzheimer disease.