NMDA/L-Type Calcium Channel BlockersCalcium overload in neuronal cells leads to celldeath.Two major routes for calcium entry into cells are theNMDA receptor/ion channel as well as the L-type calciumchannel.NGP1-01 is a dual-mechanism drug which blocks both theNMDA receptor/ion channel as well as the L-type calciumchannel, with resulting neuroprotective activity shownin vivo.DAT inhibition by NGP1-01 may be additionally useful intreatment of the motor symptoms of PD. The gene discussed is GNL2; the disease is Parkinson disease.