INS and type 2 diabetes mellitus: An example of what to expect is afforded by a proteomic analysis of individuals at risk to type 2 diabetes discerning varying risk according to single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-delta gene (PPARD), i.e. rs1053049, rs6902123, and rs2267668, allowing prediction of improvement of mitochondrial function, aerobic physical fitness, and insulin sensitivity by life style intervention, as well as consequent distribution of adiposity, hepatic fat storage, and relative muscle mass.68