Early nephromegaly, as well as both glomerular hyperfiltration and microalbuminuria, previously thought limited to type 1 diabetes, are now recognized as equally prevalent in type 2 diabetes.6 Lack of precision in diabetes classification provokes confusing terms such as “insulin requiring” to explain treatment with insulin in persons thought to have resistant type 2 diabetes. The gene discussed is INS; the disease is type 2 diabetes mellitus.