BTG3 and anemia (phenotype): Side effects in the aminoguanidine group included a transient flu-like syndrome, worsening anemia, and development of antinuclear autoantibodies (ANA).27 A similar study in 599 subjects with type 2 diabetes enrolled in 84 centers in Canada and the US was interrupted because of liver function abnormalities in the aminoguanidine treated group.