FTL and hydrops fetalis: Importantly, it was observed that greater than 50% of mutant homopolymers that were precipitated by the addition of iron (3500 iron atoms per 24-mer) were re-solubilized by incubation with DFX (Baraibar et al., 2008), highlighting chelation as a major in vitro modulator of MT-FTL aggregation, which is an important marker for HF in vivo.