LCN2 is present in the active phases of multiple sclerosis in both rodent models and in humans (Berard et al., 2012; Marques et al., 2012), but decreased in the cerebrospinal fluid of individuals with mild cognitive impairment (Choi et al., 2011; Naude et al., 2012). The gene discussed is LCN2; the disease is Cognitive impairment.