Whilst Garber and colleagues did not demonstrate a concordant increase in virus titres, it is notable that a decrease in IE gene expression and HSV-1 replication was observed in mouse neuroblastoma cell lines stably expressing the primary LAT (either in its entirety or with the sequence 3′ of the LAT 2 kb intron deleted; Mador et al., 1998). The gene discussed is LAT; the disease is neuroblastoma.