Another tumour suppressor gene that is frequently inactivated in human cancers due to mutations is p53 which has been reported to induce TP53-induced glycolysis and apoptosis regulator an enzyme that degrades 2,6-fructose bisphosphate, which is an allosteric activator of phoshofructokinase 1 (PFK1) the enzyme that redirects glucose into the pentose phosphate pathway [97]. This evidence concerns the gene TP53 and cancer.